The Highest Level of Government 

nucleoli consist of three distinguishable regions: the fibrillar center, dense fibrillar component, and granular component

The nucleolar fibrillar center is a subcompartment of the nucleolus:

Formal organization

A secondary group that is organized to achieve specific goals and tends to be large and impersonal

with a clear fibrillar structure:

where the genes for pre-rRNA 45S are being expressed

Gene expression is the process by which the information encoded in a gene is turned into a function. The activity, role, value or purpose of a part, activity, or trait of an organism

The fibrillar center being the location for an elite government organization of the society’s greatest minds that look at the coded information in RNA and turns it into the message for society’s values and purposes in life. Feeding a new culture and a new normal based on a number of hypotheses as they work with the secondary level of elites to transform the information from one form into another. Using the information as a means to create laws based on organized information and logic instead of emotion, faith or popular opinion. This lower level of elites are considered a form of working class and regularly do the busywork for the high elite. 

What is RNA do?

to create proteins via translation.

What are proteins?

Proteins are large, complex molecules that play many critical roles in the body.

Critical theory:

 a worldview that challenges the idea of a single truth and aims to understand human experiences to bring about social change

Putting together different ideas thoughts and values to make a whole which is new and different

The creation of institutions that teach this worldview. Schools, universities social clubs etc. trickle down from the high elite down to the secondary elite and the education system for their families. While the secondary elite are at a lower rank it is also recognized that the workers still play an important role in production and are to be treated as deserved. 

They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs.

This organization and its institutions oversee other forms of government and are at the heart of the world. The secondary level of government and its workers are excited of the new developments within their society.

RNA carries genetic information that is translated by ribosomes

What are ribosomes?

A ribosome is an intercellular structure

An intergalactic base of operations, study and education. This base has five operations 

the site of protein synthesis in the cell. 

Transcription

An example of this is going from audio to writing so this base could capture signals to transcribe them into a written language. The signal becomes a coded message

Translation

The coded message gets translated by a team of experts into written word 

Initiation

The original writing is given to the organization who keep it private and is not for public distribution however the new worldviews and advancements in the culture are taught

Elongation

The message is altered from short and crude to long a elaborated before and ideology is created from it

Termination

The completed protein is then released into the cytoplasm

Once the message has reached its full potential it is sent back out into space for another species to do the same

The ribosome reads the messenger RNA sequence and translates that genetic code into a specified string of amino acids,

What are amino acids?

Amino acids are required for the synthesis of body protein

Synthesis in this case being:

the combination of ideas to form a theory or system.

Meetings are held between the elites in government and scientists to take the information received and put together both a hypothesis and associated thought process before anything gets released to the public 

into various proteins necessary for cellular processes

Cellular processes are the interconnected network of functions that regulate what is essential to sustain life

What is released to the other levels of government is a network of systems to keep the world functioning at its best to sustain quality of life and productivity. To keep the public working, buying, spending, trading, creating and consuming.

The granular material (also known as “pars granulosa”)

the region of the nucleolus where ribosomal subunit assembly is occurring

Before the information gets to the public it is reduced into a more primitive form, simplified and made more understandable to those with limited knowledge and education

contains pre-ribosomal particles that are densely packed and is the site where ribosomes start to assemble

Old information is broken apart and repackaged into a product for consumption.

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The second highest level of government 

housing the cell's genome, the nucleus serves both as the repository of genetic information and as the cell's control center

All the documents and records of the DNA and RNA translations are kept in a secure vault within the seat of power. A secret city was constructed for the elites since they are handling very sensitive information and must be kept away from mainstream society.

Anatomically the nucleus is made up of several components:

nuclear pore complexes

ions to freely pass, or diffuse, into or out of the nucleus

One thing that is arguable is for the distribution of wireless electricity, ionic energy, and who should have access to it outside of the city 

There are two systems here. One being somewhat capitalist in a sense that the culture prides itself on its private and personal ownership 

private actors own and control property in accord with their interests, and demand and supply freely set prices in markets in a way that can serve the best interests of society

To diffuse is to spread out or become transmitted

Social integration

The degree to which an individual feels connected to the other people in his or her group or community

nuclear lamina,

The nuclear lamina is an essential component of metazoan cells.

metazone being division of labour

The work process for the day is broken down into a number of tasks, with each task performed by a separate person or group 

The main purposes are for the development of ideas and concepts as they are prepared for exchange with ET’s and the public. What types of systems are going to be implemented to shape the cultures of the public?

chromosomes are made up of the following:

Centromere

The centromere appears as a constricted region of a chromosome and plays a key role in helping the cell divide up its DNA during division

A heavily restricted area where the information is prepared for ET’s

(mitosis and meiosis). Specifically, it is the region where the cell's spindle fibers attach.

mitosis

mitosis, the process of making new body cells

One of the biggest projects is creating new worlds and civilizations as a group of elites meet with extraterrestrials

meiosis

There is also the discussion of seeding a planet that is a good candidate with life to see if it can survive and thrive 

kinetochore,

large protein assemblies that connect chromosomes to microtubules

Microtubules help support the shape of a cell

A decision is made on what level of society is to be created there is an entire system to categorize the level of the sophistication for that world 

The spindle is the structure that pulls the chromatids to opposite ends of the cell during the cell division processes of mitosis and meiosis

When it comes to seeding a planet with life any species will do is far from the reality of this process. There is a lot of consideration to make a functional ecosystem 

chromatin,

to package DNA into a unit capable of fitting within the tight space of a nucleus

When the information and the “starter kit” is created for ET’s it has to fit a tight space. So, the technology for this starter kit is sophisticated enough to store the information for every species that is destined for this new world.

secondary constriction,

telomere,

The information that is developed has to be mathematically sound 

prevent chromosomal degradation

To ensure quality this the information in this kit is kept intact and not simplified since every detail is crucial 

centromere,

A place of business where highly classified information that has been exchanged between two species is analyzed 

matrix

Copies are created to run simulations in what seems like a parallel universe when really they are parallel operations

nucleoplasm

An artificial universe is simulated in this study 

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The nuclear events occurring during apoptosis include changes at the molecular level (i.e. DNA cleavage,

A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA

One of the first things done beyond the information border is the manipulation of the knowledge that was gained in order to make it “Appropriate” a mutated form of the message is created called splicing. This is something that is regarded as extremely illegal as it involves “cutting and rearranging” the message

modifications of nuclear polypeptides,

 a single-stranded chain

The information has been reduced to a biased version of what was originally there the other viewpoints censored and only one interpretation is now allowed. Completely unacceptable and an insult but, this is what the new regime does, not only to extraterrestrials but to the lower levels of government. A completely controlled society. It is a fact that an ignorant society is easily manipulated and by controlling what they know you can control their opinions and beliefs without them really knowing.

and proteolysis of several proteins important for cell maintenance

the breakdown of proteins into smaller polypeptides or amino acids

The new regime demands that society is to be conditioned to be less intelligent and too apathetic  to take any action 

and, consequently, alterations at the morphological level

 the internal structure of words

Changes are to be made in the language people use, how they form relationships, every aspect of their lives controlled. Under the illusion that they are making choices when really they’re only able to comprehend the information that has been fed to them

chromatin condensation,

a reduction of volume due to a spatial organization into densely packed higher-order structures

This manipulation and control is handled by the high elite. It has been decided to make the information as short as possible and condition the people to have shorter attention spans and more impatient 

spatial being your ability to see and understand the relationships between shapes, spaces, and areas.

nuclear shrinkage,

The inner circle of world leaders that are aware of what is going on and are on board with the new regime gets smaller as even nations who are known for corruption want nothing to do with this. They have thrown up their hands and said absolutely not! We want no part in this!

and DNA fragmentation

DNA fragmentation is the process of DNA strands breaking apart into smaller pieces fragmentation gradually accumulates in a cell

Society is conditioned through the consumption of media to have shorter and shorter attention spans and consumption of media that is designed to make society as a whole less intelligent. Everything in the culture is to be shorter and faster, if you look at modern society and social media you will see what I mean 

The four stages of apoptosis are:

induction,

The two main pathways of apoptosis are extrinsic

not part of the essential nature of someone or something; coming or operating from outside

People are encouraged more and more to ignore their instincts while an agenda is pieced together outside the realm of mainstream society 

and intrinsic

As well as intruding on people’s personal lives 

as well as a perforin/granzyme pathway.

essential components of the cytotoxic granules

Creating a toxic environment for those who would otherwise thrive deeming them as either broken or a “problem” in society 

present in cytotoxic T lymphocytes and natural killer cells.

Attempts to destroy those who follow the anti corruption movements with humiliation and alienation 

Each requires specific triggering signals to begin an energy-dependent cascade of molecular events

With the information gathered from monitoring the public begins the perpetual “War on (fill in the blank)” in the name of public safety as people’s freedoms are slowly stripped away 

early phase,

Cells become smaller, with a denser cytoplasm and more tightly packed organelles

The energy of the world becomes “heavier” as there is more negativity than ever while the population explodes 

translocation

moves to the outer leaf of the plasma membrane

The cry for help of the public has reached ET’s as the world is at a breaking point 

Signaling molecules downstream of the death receptors are activated

Elites on the lower levels are given the order to issue lockdowns each of them stricter than the last 

pathway activation

The anti corruption movements organize and are ready for the most important war

mid phase

The mid phase is when the intrinsic and extrinsic apoptosis pathways converge.

The agenda of ET’s takes the side of the public who don’t want this regime as acceptable and together they will not stand for it 

late phase

The late stage of apoptosis is characterized by DNA fragmentation(karyorrhexis), which starts upon completion of nuclear condensation 

The world itself begins to rebel and “bleed” toxic substances 

Necroptosis is a type of programmed cell death that involves the translocation…

a genetic change

The process of making information appropriate has begun to change the nature of the people. They have started to have more and more personality disorders unlike what has been seen before in history. These issues the result of environmental conditioning

occurs when a piece of a chromosome breaks off and attaches to another chromosome

A snippet of one person’s culture is stripped away from them as it gets attached to a larger and more dare I say commercial culture. In entertainment this is done to sell products and misconceptions that are profitable 

Let’s revisit the parts of the chromosome 

Chromatids

Chromatids allow cells to store two copies of their DNA in preparation for cell division.

In a civilized society the information obtained by the DNA is used as instructions for designing new worlds and making sure the life is successful.

In Locket’s society the DNA is manipulated and used to create experimental creatures on young planets. Much like the story of the Anunnaki 

Telomeres

Telomeres prevent the ends of chromosomes from fraying, tangling, or degrading. 

Normally this would be about maintaining a culture’s integrity and not allowing what is sacred to become lost in commercialism. This has been changed to protect the regime and its reputation 

They also protect chromosomes from DNA damage, DNA end-joining, and accidental DNA recombination

The new “appropriate” DNA knowledge is still however carefully crafted so that it can be deemed acceptable and deceive the lower levels of government 

recombination

DNA recombination is the process of breaking and rejoining DNA segments to create new nucleotide sequences It's essential for generating genetic diversity and maintaining genome integrity

Exciting research in both societies however used for very different reasons. In Locket’s world the concept of this process is so the same information can be used over and over and seem like a new thing slowly brainwashing the people. Since Organelle has no income under the new regime this process is crucial 

Chromatin

Chromatin's main function is to condense DNA into a compact form that can fit within the nucleus of a cell.

All the knowledge acquired, as lengthy as it is, is to be put into compact form and to be stored away where only top government officials can access. The information is for the eyes of the elites only and only the appropriate information is to be released.

Histones

Histones strengthen DNA to allow replication help control gene activity

There’s a group of people who do this as a job as they prepare the information to be put into the vault. The examine the information and organize it in a way to make it the most convincing to then be reproduced into a law similar to religious dogma 

Kinetochore

The kinetochore acts as a signaling hub to regulate the cell cycle

A military base that is used for surveillance of everyone to make sure they are behaving in a way that follows the world’s development as it goes through it’s cycles of cultural attitudes 

Telomeric proteins

To grant the power to the high elites by stabilizing their position of power and to bring certain cultural norms to an end 

or when pieces from two different chromosomes trade places.

An exchange where the social laws of one culture is traded with another and they call it progress. After the exchange each culture puts their own spin on the new social norms 

and a process in protein synthesis..

Which includes:

Transcription

where genetic instructions from DNA are transferred to mRNA in the nucleus

What is mRNA?

mRNA stands for messenger RNA and it’s function being the process of transferring genetic information from DNA into a cell

The knowledge that was gained is repurposed into instructions for a global system of government 

Translation

Translation is the process of converting genetic information in RNA into functional proteins

Proteins provide structure and support for cells Some proteins act as chemical messengers

The information in the RNA in a fair society would be used to shape the curriculum in education. Instead it is being used as a means to fund the government and to monitor communication of citizens 

Elongation

 a biological process that involves the addition of amino acids to a growing chain

Attaching details acquired elsewhere to a written order of expected behaviour 

Termination

the end of transcription or translation, or the process of ending cellular signaling

The discontinuation of new knowledge being brought to education and instead have these institutions to program the youth to consume more products and to give them the same message over and over rearranged to appear on the surface as a new thing 

…of signaling proteins to the nucleus

Lower levels of power take concerns to the secondary elite since they cannot contact the high elite 

Following necroptosis induction, 

RIPK3 is activated 

What is RIPK3?

an enzyme that is a vital component of necrosomes,

Being Fas-associated protein

Fas-associated death domain:

is an adapter protein that connects the Fas-receptor

to procaspases 8 and 10

to form the death-inducing signaling complex (DISC)

with death domain leading to activation of the pseudokinase

 a protein kinase that lacks the ability to catalyze reactions,

but still plays a role in cell signaling

also known as signal transduction, is the process by which cells communicate with each other and their environment

mixed lineage kinase

Or MLK is a protein kinase that is part of the mitogen-activated protein or MAP

enzymes that regulate cellular responses to stimuli, such as heat shock

followed by a rapid plasma membrane rupture

and inflammatory response through the release of damage-associated molecular patterns and cytokines

small proteins that are crucial in controlling the growth and activity of other immune system cells like T Cells 

which trigger caspase-independent programmed necrosis

occurs when caspases are not activated

a family of enzymes that are central to apoptosis

cysteine proteases

that cleave proteins

after an aspartic acid residue. 

This process leads to changes in cell morphology

MLKL is activated in the nucleus,

What is MLKL?

the terminal protein in the pro-inflammatory necroptotic cell death program

Necroptosis is a type of programmed cell death that is similar to necrosis, but is caspase-independent.

It's governed by the receptor-interacting protein kinase 1 (RIP1),

regulates the decision between cell death and survival

RIP3,

RIP3 is a vital part of the necrosome, a signaling complex

that triggers caspase-independent programmed necrosis. 

Necroptosis is activated by pattern recognition receptors

and death receptor ligands from the innate immune system

and mixed lineage kinase domain-like protein (MLKL).

the terminal protein in the pro-inflammatory necroptotic cell death program

and after their cooperative nuclear export,

they contribute to cytosolic necrosome formation.

Consequently, the export of RIPK3 and MLKL from the nucleus to the cytosol 

Something good is about to happen