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The elite meet to discuss the visitors and the results of the simulation 

Centuries of observation has shown there are five docile personality types that exist in Organelle and five hostile ones 

Some more intelligent than others 

Docile personality types:

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Totipotent:

Totipotent cells undergo zygotic genome activation (ZGA), which involves the synthesis of new transcripts

Totipotent cells undergo changes in DNA methylation, histone modifications, and chromatin remodeling

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Pluripotent:

Pluripotent stem cells can differentiate into the ectoderm, mesoderm, and endoderm, which can give rise to all cell types

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Multipotent:

unspecialized meaning they have not yet “decided” what type of adult cell they will be. They can self-renew and make two new stem cell. They can differentiate to make multiple types of cells

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Oligopotent:

Oligopotent stem cells have a more restricted differentiation potential than multipotent or pluripotent stem cells

Oligopotent stem cells can differentiate into cells of the blood and immune systems. For example, myeloblast stem cells produce white blood cells, and lymphoid stem cells differentiate into lymphocyte

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Unipotent:

Unipotent stem cells can only differentiate into one cell type

Unipotent stem cells are found in adult organ tissues that are dedicated to a specific cell lineage

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Hostile Personalities:

Innate immunity

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Adaptive immunity

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Autoimmunity

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Humoral immunity

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Cell-mediated immunity

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The Walk of Virtue 

Is a message for the people 

Chromosomes gather: Chromosomes move to opposite poles of the cell, where they gather into two sets

Nuclear membranes form: A membrane forms around each set of chromosomes, creating two new nuclei

Chromosomes decondense: Chromosomes return to their "stringy" form

Cell division: The cell pinches in the middle and divides again, creating four daughter cells

Daughter cells are haploid: Each daughter cell has half the number of chromosomes as the original cell. 

Daughter cells have new gene mixtures: Each daughter cell has a new combination of genes due to recombination during meiosis

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Anaphase II is a stage of meiosis II where sister chromatids separate and move to opposite poles of the cell

Centromere splitting: The centromere of each chromosome splits 

Chromatid separation: Sister chromatids separate at the centromere 

Microtubule attachment: Microtubules from the spindle attach to the kinetochore of each sister chromatid 

Chromatid movement: Microtubules pull the sister chromatids to opposite poles of the cell 

Cellular checkpoint: A checkpoint ensures that chromosomes formed after meiosis I have not changed 

Cell elongation: Microtubules not attached to the kinetochore pull apart to elongate the cell 

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Metaphase II is a stage of meiosis II where chromosomes line up in the middle of a cell to form a metaphase plate

 Chromosomes line up: Chromosomes line up in pairs of sister chromatids along the metaphase plate

Microtubules attach: Microtubules from the centrosomes at opposite poles of the cell attach to the kinetochores of each chromosome

Centrioles at opposite poles: Centrioles are located at opposite poles of each daughter cell

Metaphase plate forms: The chromosomes align at the equator of the cell to form the metaphase plate

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Prometaphase II is a stage of meiosis II when the nuclear envelope breaks down and the spindle is fully formed. During this stage, each sister chromatid forms a kinetochore that attaches to microtubules from opposite poles

Nuclear envelope breakdown: The nuclear membrane breaks down into small vesicles, allowing spindle microtubules to access the cell's genetic material

Kinetochore formation: A protein structure called a kinetochore forms around the centromere, which is the central point of the sister chromatids

Microtubule attachment: Microtubules from the centrosomes at the poles of the spindle attach to the kinetochores

Chromosome movement: The chromosomes move back and forth until they align on the metaphase plate in the center of the spindle

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Prophase II is a stage of cell division in meiosis that involves the condensation of chromosomes and the breakdown of the nuclear envelope

Chromosomes condense: Chromosomes condense into visible X-shaped structures

Nuclear membrane dissolves: The nuclear membrane breaks down, allowing the chromosomes to become visible

Spindle fibers form: Centrioles migrate to opposite ends of the cell and begin to form spindle fibers. 

Chromosomes move: The chromosomes begin to move toward the equator of the cell. 

Kinetochore proteins assemble: Kinetochore proteins assemble on the outer chromatids of each chromosome

Meiotic spindle attaches: The meiotic spindle attaches to the kinetochores.

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Telophase I is a stage of meiosis where chromosomes gather at the poles of a cell, and the cell prepares to divide into two daughter cells

Homologous chromosomes separate: Homologous chromosomes separate and move to opposite sides of the cell

Nuclear envelope reforms: The nuclear envelope reforms around each set of chromosomes, creating two new nuclei

Cytokinesis occurs: The cell pinches in the middle, forming two daughter cells

Chromosomes decondense: The chromosomes de-condense back into chromatin

Spindle apparatus disappears: The spindle apparatus disappears

Daughter cells are not identical: The daughter cells are not identical because crossing over occurs, making each chromosome unique

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Anaphase 1 is the third stage of meiosis I, and is characterized by the separation of homologous chromosomes

Homologous chromosome separation: Homologous chromosomes separate and move to opposite ends of the cell

Microtubule activity: Microtubules shorten and lengthen, pulling and pushing chromosomes and centrosomes

Cell elongation: The cell elongates as it prepares to divide

Spindle apparatus: The spindle apparatus moves chromosomes to the poles of the cell

Kinetochore microtubules: Kinetochore microtubules shorten, pulling homologous chromosomes to opposite poles

Non-kinetochore microtubules: Non-kinetochore microtubules lengthen, pushing centrosomes apart

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